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Int J Mol Sci. 2012;13(3):3366-81. doi: 10.3390/ijms13033366. Epub 2012 Mar 12.

Preparation and characterization of new nano-composite scaffolds loaded with vascular stents.

Author information

1
Institute of Prosthodontics, School of Stomatology, Tongji University, 399 Yanchang Road, Shanghai 200092, China; E-Mails: xuhongzhen0531@163.com (H.X.); cipher44444444@hotmail.com (J.S.).

Abstract

In this study, vascular stents were fabricated from poly (lactide-ɛ-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycaprolactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering.

KEYWORDS:

electrospinning; mechanical property; nano-composite scaffold; tissue engineering

PMID:
22489156
PMCID:
PMC3317717
DOI:
10.3390/ijms13033366
[Indexed for MEDLINE]
Free PMC Article
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