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Pediatr Surg Int. 2012 Jul;28(7):737-40. doi: 10.1007/s00383-012-3081-y. Epub 2012 Apr 10.

A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma.

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  • 1Section of Pediatric Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792-7375, USA.


Lipoblastoma is a rare benign neoplasm of embryonic white fatty tissue primarily found in the extremities of children <3 years old (Batanian et al., Cancer Genet Cytogenet 125(1):10-13, 2001; McVay MR et al., J Pediatr Surg 41(6):1067-1071, 2006; Kamal et al., J Pediatr Surg 46(7):E9-E12, 2011). Translocations affecting the 8q11-13 region are commonly reported with lipoblastoma and proper diagnosis requires cytogenetic analysis to distinguish it from malignant myxoid liposarcoma (Miller et al., J Pediatr Surg 32(12):1771-1772, 1997; Morerio et al., Pediatr Blood Cancer 52(1):132-134, 2009). We describe an additional case of lipoblastoma containing a new translocation t(3;8)(p13;q21.1), which has not previously been reported in a healthy asymptomatic child.

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