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Urol Clin North Am. 2012 May;39(2):133-48, v. doi: 10.1016/j.ucl.2012.01.006. Epub 2012 Feb 23.

The surgical approach to multifocal renal cancers: hereditary syndromes, ipsilateral multifocality, and bilateral tumors.

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Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, CRC, Room 1-5940, Bethesda, MD 20892, USA.


Although the management of sporadic renal tumors is challenging enough, dealing with those with bilateral, multifocal, and hereditary kidney cancer adds an additional level of complexity. A clinician managing this patient population must understand the hereditary syndromes and the genetic testing available. Treating physicians must be familiar with enucleative surgery, complex or multiple tumor partial nephrectomy, complex renal reconstruction, re-operative renal surgery, and active surveillance strategies. With proper management, most patients affected with bilateral, multifocal, or hereditary RCC can have a long life expectancy while maintaining adequate renal function.

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