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Lung Cancer. 2012 Jul;77(1):232-4. doi: 10.1016/j.lungcan.2012.03.014. Epub 2012 Apr 7.

Thymoma and solid-organ transplantation.

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1
Pulmonology Department, Rangueil-Larrey University Hospital, Toulouse, France. nicolas.guibert@hotmail.fr

Abstract

Solid-organ-transplant recipients are at high risk of developing cancer, including thoracic malignancies. Herein, we report on two cases of thymoma in solid-organ recipients. One case was a female kidney-transplant recipient who had a type B2, Masaoka stage IVA thymoma that was treated by extended surgical resection followed by postoperative radiation therapy. The second case was type A Masaoka II thymoma that occurred after a liver transplant. The role of EBV in the oncogenesis of thymoma is controversial. We suggest that viruses may induce neoplasms in this specific population, as observed in post-transplant lymphoproliferative disorders. However, Epstein-Barr-encoded RNA (EBER) was negative in both patients.

PMID:
22487431
DOI:
10.1016/j.lungcan.2012.03.014
[Indexed for MEDLINE]
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