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Curr Opin Neurobiol. 2012 Oct;22(5):747-53. doi: 10.1016/j.conb.2012.03.006. Epub 2012 Apr 7.

OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease.

Author information

1
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, University of California San Francisco, San Francisco, CA 94143, USA.

Abstract

Recent discoveries concerning the architecture and cellular dynamics of the developing human brain are revealing new differences between mouse and human cortical development. In mice, neurons are produced by ventricular radial glial (RG) cells and subventricular zone intermediate progenitor (IP) cells. In the human cortex, both ventricular RG and highly motile outer RG cells generate IP cells, which undergo multiple rounds of transit amplification in the outer subventricular zone before producing neurons. This creates a more complex environment for neurogenesis and neuronal migration, adding new arenas in which neurodevelopmental disease gene mutation could disrupt corticogenesis. A more complete understanding of disease mechanisms will involve use of emerging model systems with developmental programs more similar to that of the human neocortex.

PMID:
22487088
PMCID:
PMC3402619
DOI:
10.1016/j.conb.2012.03.006
[Indexed for MEDLINE]
Free PMC Article

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