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Can J Physiol Pharmacol. 2012 Jun;90(6):765-70. doi: 10.1139/y11-134. Epub 2012 Apr 9.

Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

Author information

1
Department of Pharmacology and Alberta Diabetes Institute, Li Ka Shing Centre, University of Alberta, Edmonton, AB T6G 2E1, Canada. jm33@ualberta.ca

Abstract

The endocrine pancreas is critically important in the regulation of energy metabolism, with defective insulin secretion from pancreatic islet β-cells a major contributing factor to the development of type 2 diabetes. Small ubiquitin-like modifier (SUMO) proteins have been demonstrated to covalently modify a wide range of target proteins, mediating a broad range of cellular processes. While the effects of SUMOylation on β-cell gene transcription have been previously reviewed, recent reports indicate roles for SUMO outside of the nucleus. In this review we shall focus on the reported non-nuclear roles of SUMOylation in the regulation of β-cells, including SUMOylation as a novel signaling pathway in the acute regulation of insulin secretion.

PMID:
22486776
DOI:
10.1139/y11-134
[Indexed for MEDLINE]

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