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Bull Exp Biol Med. 2011 Oct;151(6):726-30.

Magnetic resonance imaging of endothelial cells with vectorized iron oxide nanoparticles.

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Department of Medical Nanobiotechnology, Medicobiological Faculty, Russian State Medical University, Ministry of Health Care and Social Development of Russian Federation, Moscow, Russia.


We propose a method for obtaining superparamagnetic nanoparticles based on iron oxide and their water suspensions. The structure and size of nanoparticles were confirmed by transmission electron microscopy, dynamic light scattering, and X-ray diffraction analysis. The nanoparticles also contained a fluorescent dye Dil C18. Cytotoxicity of obtained aqueous suspension was studied by MTT assay; low toxicity of nanoparticles was demonstrated. High T2-relaxivity of nanoparticles allows using them as a contrast agent for MRI. After incubation of cerebellar sections with nanoparticles vectorized with antibodies to antigen AMVB1, specific visualization of blood vessels was detected.

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