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Nat Methods. 2012 Jun;9(6):579-81. doi: 10.1038/nmeth.1982. Epub 2012 Apr 4.

Accurate identification of human Alu and non-Alu RNA editing sites.

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1
Department of Genetics, Stanford University, California, USA.

Abstract

We developed a computational framework to robustly identify RNA editing sites using transcriptome and genome deep-sequencing data from the same individual. As compared with previous methods, our approach identified a large number of Alu and non-Alu RNA editing sites with high specificity. We also found that editing of non-Alu sites appears to be dependent on nearby edited Alu sites, possibly through the locally formed double-stranded RNA structure.

PMID:
22484847
PMCID:
PMC3662811
DOI:
10.1038/nmeth.1982
[Indexed for MEDLINE]
Free PMC Article
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