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Biochim Biophys Acta. 2012 Jun;1817(6):920-7. doi: 10.1016/j.bbabio.2012.03.025. Epub 2012 Mar 30.

Heme A biosynthesis.

Author information

1
Microbiology Group, Department of Biology, Lund University, Sweden. Lars.Hederstedt@biol.lu.se

Abstract

Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes.

PMID:
22484221
DOI:
10.1016/j.bbabio.2012.03.025
[Indexed for MEDLINE]
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