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Cell Metab. 2012 Apr 4;15(4):432-7. doi: 10.1016/j.cmet.2011.11.013.

Orchestration of metabolism by macrophages.

Author information

1
Singapore Immunology Network, Agency for Science, Technology, and Research, #04-06 Immunos, 8A Biomedical Grove, Singapore, Republic of Singapore. subhra_biswas@immunol.a-star.edu.sg

Abstract

Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity, and inflammation. Macrophage products also impact metabolism, as illustrated by obesity-associated pathologies. Defining the mechanisms regulating macrophage metabolic activity and orchestration of metabolism by macrophages is crucial to pathology and therapeutic intervention.

PMID:
22482726
DOI:
10.1016/j.cmet.2011.11.013
[Indexed for MEDLINE]
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