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Curr Opin Virol. 2012 Apr;2(2):134-41. doi: 10.1016/j.coviro.2012.02.005. Epub 2012 Mar 21.

Broadly neutralizing antibodies against influenza virus and prospects for universal therapies.

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1
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Vaccines are the gold standard for the control and prevention of infectious diseases, but a number of important human diseases remain challenging targets for vaccine development. An influenza vaccine that confers broad spectrum, long-term protection remains elusive. Several broadly neutralizing antibodies have been identified that protect against multiple subtypes of influenza A viruses, and crystal structures of several neutralizing antibodies in complex with the major influenza surface antigen, hemagglutinin, have revealed at least 3 highly conserved epitopes. Our understanding of the molecular details of these antibody-antigen interactions has suggested new strategies for the rational design of improved influenza vaccines, and has inspired the development of new antivirals for the treatment of influenza infections.

PMID:
22482710
PMCID:
PMC3368890
DOI:
10.1016/j.coviro.2012.02.005
[Indexed for MEDLINE]
Free PMC Article
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