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Cell Stem Cell. 2012 Apr 6;10(4):353-4. doi: 10.1016/j.stem.2012.03.012.

In epigenetic therapy, less is more.

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1
USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9601, USA.

Abstract

How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells.

PMID:
22482500
DOI:
10.1016/j.stem.2012.03.012
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