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Ocul Surf. 2012 Apr;10(2):108-16. doi: 10.1016/j.jtos.2012.02.001. Epub 2012 Feb 8.

Report of the TFOS/ARVO Symposium on global treatments for dry eye disease: an unmet need.

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Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.


In September 2010, a Symposium in Florence, Italy, was held to address the unmet need for global treatments for dry eye disease (DED). It was sponsored by The Tear Film & Ocular Surface Society (TFOS; and co-sponsored by the Association for Research in Vision & Ophthalmology ( The Symposium objectives were two-fold: first, to discuss accepted and emerging clinical endpoints of DED with regulatory experts from around the world; and second, to consider how to improve clinical trials of treatments for DED. The Symposium focused on the personal and collective burden of DED, as well as the developmental and regulatory challenges associated with generating new DED therapeutics. This article provides a synopsis of many of the presentations, discussions and recommendations of this Symposium.

[Indexed for MEDLINE]

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