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Clin Dev Immunol. 2012;2012:731486. doi: 10.1155/2012/731486. Epub 2012 Mar 15.

Myeloid-derived suppressor cells participate in preventing graft rejection.

Author information

1
Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.

PMID:
22481970
PMCID:
PMC3312340
DOI:
10.1155/2012/731486
[Indexed for MEDLINE]
Free PMC Article

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