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Pediatr Infect Dis J. 2012 Jul;31(7):722-5. doi: 10.1097/INF.0b013e31825051d4.

Factors associated with loss of penicillin G concentrations in serum after intramuscular benzathine penicillin G injection: a meta-analysis.

Author information

1
Henry M. Jackson Foundation at The Operational Infectious Diseases Department, Naval Health Research Center, San Diego, CA 92106, USA. michael.broderick@med.navy.mil

Abstract

BACKGROUND:

An interval of 3-4 weeks between intramuscular injections of 1.2 million units of benzathine penicillin G as prophylaxis against group A streptococcal infection is recommended by health organizations for patients with pediatric rheumatic fever and heart disease.

METHODS:

We reviewed the literature for evidence of the persistence of serum penicillin G during the first 4 weeks after the recommended dose of benzathine penicillin G.

RESULTS:

The weighted-mean concentration was <0.02 µg/mL by 3 weeks after the initial dose. Weighted means were lower in studies done after 1990 than before (P<0.01), in studies dealing with secondary versus primary prophylaxis (P<0.01) and in studies in children versus those in adults (P<0.02).

CONCLUSIONS:

Recommendations for benzathine penicillin G prophylaxis may need reevaluation.

PMID:
22481428
DOI:
10.1097/INF.0b013e31825051d4
[Indexed for MEDLINE]

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