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Schizophr Res. 2012 Jul;138(2-3):157-63. doi: 10.1016/j.schres.2012.03.019. Epub 2012 Apr 3.

Hippocampal novelty activations in schizophrenia: disease and medication effects.

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  • 1Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States.


We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

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