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Trends Cell Biol. 2012 May;22(5):241-9. doi: 10.1016/j.tcb.2012.02.007. Epub 2012 Apr 3.

Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis.

Author information

1
Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. dumont@ijm.univ-paris-diderot.fr

Abstract

The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models.

PMID:
22480579
PMCID:
PMC3348331
DOI:
10.1016/j.tcb.2012.02.007
[Indexed for MEDLINE]
Free PMC Article

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