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Cell Mol Life Sci. 2012 Sep;69(18):3027-36. doi: 10.1007/s00018-012-0973-x. Epub 2012 Apr 4.

Paraspeckle nuclear bodies--useful uselessness?

Author information

1
RNA Biology Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan. nakagawas@riken.jp

Abstract

The nucleus of higher eukaryotes, such as humans and mice, is compartmentalized into multiple nuclear bodies, an organization that allows for the regulation of complex gene expression pathways that are characteristic of these organisms. Paraspeckles are recently discovered, mammalian-specific nuclear bodies built on a long, non-protein-coding RNA, NEAT1 (nuclear-enriched abundant transcript 1), which assembles various protein components including RNA-binding proteins of the DBHS (Drosophila behavior and human splicing) family. Paraspeckles have been proposed to control several biological processes, such as stress responses and cellular differentiation, but their function at the whole animal level remains unclear. In this review, we summarize a series of studies on paraspeckles that have been carried out in the decade since their discovery and discuss their physiological function and molecular mechanism.

PMID:
22476590
PMCID:
PMC3428521
DOI:
10.1007/s00018-012-0973-x
[Indexed for MEDLINE]
Free PMC Article

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