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Neurosci Biobehav Rev. 2012 Jul;36(6):1510-31. doi: 10.1016/j.neubiorev.2012.03.007. Epub 2012 Mar 28.

The young brain and concussion: imaging as a biomarker for diagnosis and prognosis.

Author information

1
Center for Pain and the Brain, Children's Hospital Boston, Harvard Medical School, United States.

Abstract

Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.

PMID:
22476089
PMCID:
PMC3372677
DOI:
10.1016/j.neubiorev.2012.03.007
[Indexed for MEDLINE]
Free PMC Article

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