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Arch Med Res. 2012 Feb;43(2):159-65. doi: 10.1016/j.arcmed.2012.03.007. Epub 2012 Apr 2.

Airflow obstruction in never smokers in five Latin American cities: the PLATINO study.

Author information

1
National Institute of Respiratory Diseases, Mexico City, Mexico. perezpad@servidor.unam.mx

Abstract

BACKGROUND:

Although chronic obstructive pulmonary disease (COPD) is mostly related to tobacco smoking, a variable proportion of COPD occurs in never smokers. We investigated differences between COPD in never smokers compared with smokers and subjects without COPD.

METHODS:

PLATINO is a cross-sectional population-based study of five Latin American cities. COPD was defined as postbronchodilator FEV(1)/FVC <0.70 and FEV(1) <80% of predicted values.

RESULTS:

Among 5,315 subjects studied, 2278 were never smokers and 3036 were ever smokers. COPD was observed in 3.5% of never smokers and in 7.5% of ever smokers. Never smokers with COPD were most likely older and reported a medical diagnosis of asthma or previous tuberculosis. Underdiagnosis was as common in obstructed patients who never smoked as in ever smokers.

CONCLUSIONS:

Never smokers comprised 26% of all individuals with airflow obstruction. Obstruction was associated with female gender, older age and a diagnosis of asthma or tuberculosis.

PMID:
22475778
DOI:
10.1016/j.arcmed.2012.03.007
[Indexed for MEDLINE]

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