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J Nat Prod. 2012 Apr 27;75(4):728-34. doi: 10.1021/np3000156. Epub 2012 Apr 4.

Bis-spirolabdane diterpenoids from Leonotis nepetaefolia.

Author information

1
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, USA.

Abstract

Ten new bis-spirolabdane diterpenoids, leonepetaefolins A-E (1, 3, 5, 7, 9) and 15-epi-leonepetaefolins A-E (2, 4, 6, 8, 10), together with eight known labdane diterpenoids (11-18) as well as two known flavonoids, apigenin and cirsiliol, were isolated from the leaves of Leonotis nepetaefolia. The structures of the new compounds were determined on the basis of 1D- and 2D-NMR experiments including (1)H, (13)C, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOESY. The absolute configuration of an epimeric mixture of 1 and 2 was determined by X-ray crystallographic analysis. The compounds isolated were evaluated for their binding propensity in several CNS G-protein-coupled receptor assays in vitro.

PMID:
22475308
PMCID:
PMC3338874
DOI:
10.1021/np3000156
[Indexed for MEDLINE]
Free PMC Article

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