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Chembiochem. 2012 May 7;13(7):977-81. doi: 10.1002/cbic.201100809. Epub 2012 Mar 30.

Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.

Author information

1
QB3 Institute, University of California, Berkeley, CA 94720, USA.

Abstract

Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.

PMID:
22474005
PMCID:
PMC3477619
DOI:
10.1002/cbic.201100809
[Indexed for MEDLINE]
Free PMC Article

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