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Phytother Res. 2013 Jan;27(1):148-51. doi: 10.1002/ptr.4694. Epub 2012 Apr 4.

Pancreatic lipase inhibitory activity of phlorotannins isolated from Eisenia bicyclis.

Author information

1
Department of Food Science and Technology, Pukyong National University, Busan 608-737, Korea.

Abstract

Pancreatic lipase is a potential therapeutic target for the treatment of diet-induced obesity in humans. In an ongoing search for new pancreatic lipase inhibitors from natural sources, a methanolic extract of marine brown algae, Eisenia bicyclis, showed a significant inhibitory effect against pancreatic lipase. Bioassay-guided isolation of this methanolic extract using a pancreatic lipase inhibitory assay led to the isolation and identification of six known phlorotannins: eckol (1), fucofuroeckol A (2), 7-phloroeckol (3), dioxindehydroeckol (4), phlorofucofuroeckol A (5), and dieckol (6). The structures were established on the basis of nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Among the isolated phloroglucinol polymers, compounds 2 and 3 showed potent inhibitory effects on pancreatic lipase with IC₅₀ values ranging from 37.2 ± 2.3 to 12.7 ± 1.0 μM, respectively.

PMID:
22473750
DOI:
10.1002/ptr.4694
[Indexed for MEDLINE]

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