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Ann Neurol. 2012 May;71(5):601-13. doi: 10.1002/ana.22693. Epub 2012 Apr 4.

Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis.

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Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Quebec, Canada.


Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large-scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon-glial interactions in those children destined for diagnosis of MS.

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