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Am J Hematol. 2012 May;87 Suppl 1:S23-6. doi: 10.1002/ajh.23191. Epub 2012 Apr 4.

The literature on inhibitors: articles that influence my management of patients with hemophilia A and high-titer inhibitors.

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1
Louisiana Center for Bleeding and Clotting Disorders, Tulane University Medical Center, New Orleans, Louisiana 70112, USA. cleissi@tulane.edu

Abstract

High-titer inhibitors represent the greatest management challenge faced by clinicians who treat patients with hemophilia A, as bleeding episodes no longer respond to standard factor VIII replacement therapy. Over the last seven decades, major strides have been made in inhibitor treatment. This article focuses on the seminal clinical observations and studies that provided the foundation for these advances in hemophilia care.

PMID:
22473571
DOI:
10.1002/ajh.23191
[Indexed for MEDLINE]
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