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Nat Rev Nephrol. 2012 May;8(5):257-8. doi: 10.1038/nrneph.2012.62.

RAS blockade, hyperkalemia and AKI--look and you will find.

Author information

1
University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. robert.toto@utsouthwestern.edu

Abstract

Aliskiren combined with other inhibitors of the renin–angiotensin system increases the risk of hyperkalemia. This risk does not translate into an increased incidence of acute kidney injury, suggest the results of a meta-analysis. However, further research is needed to fully evaluate the safety of combination therapy with aliskiren.

PMID:
22473512
DOI:
10.1038/nrneph.2012.62
[Indexed for MEDLINE]

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