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Psychother Psychosom Med Psychol. 2012 Mar-Apr;62(3-4):89-94. doi: 10.1055/s-0032-1304650. Epub 2012 Apr 2.

[Neurocognitive deficits in patients with malignant brain tumors].

[Article in German]

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Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, Langerstraße 3, Munich.


This article reviews research on neurocognitive deficits in adult patients with malignant brain tumors, i. e. high-grade primary brain tumors and brain metastases. Brain tumor patients experience significant neurocognitive deficits, mainly in the domains of attention, memory, executive function and psychomotor function. Neurosurgical, radiotherapeutic or radiochemotherapeutic treatment regimens are often associated with a decline in cognitive functioning. However, such empirical observations are often confounded with the neurocognitive effects of tumor progression. Few studies investigated associations among neurocognitive deficits and distress. These studies revealed contradictory results. Similarly, research on neurocognitive deficits and health-related quality of life has resulted in equivocal evidence. Furthermore, convincing empirical evidence for the effectiveness of neurocognitive training in patients with high-grade brain tumors is lacking.

[Indexed for MEDLINE]

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