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Exp Cell Res. 2012 Jul 15;318(12):1386-93. doi: 10.1016/j.yexcr.2012.03.016. Epub 2012 Mar 24.

Cohesin in determining chromosome architecture.

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1
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. christian.haering@embl.de

Abstract

Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.

PMID:
22472347
DOI:
10.1016/j.yexcr.2012.03.016
[Indexed for MEDLINE]
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