Fracture risk by HIV infection status in perinatally HIV-exposed children

AIDS Res Hum Retroviruses. 2012 Mar;28(3):247-50. doi: 10.1089/aid.2011.0064. Epub 2011 Jul 8.

Abstract

The objective of this study was to examine the incidence of fractures in HIV-infected children and comparable HIV-exposed, uninfected (HEU) children in a multicenter, prospective cohort study (PACTG 219/219C) in the United States. The main outcome was first fracture during the risk period. Nine fractures occurred in 7 of 1326 HIV-infected and 2 of 649 HEU children, corresponding to incidence rates of 1.2 per 1000 person-years and 1.1 per 1000 person-years, respectively. The incidence rate ratio was 1.1 (95% CI 0.2, 5.5). There was no evidence of a substantially increased risk of fracture in HIV-infected compared to HEU children.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / epidemiology*
  • Acquired Immunodeficiency Syndrome / virology
  • Anti-HIV Agents / therapeutic use
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Fractures, Bone / epidemiology*
  • Fractures, Bone / etiology*
  • Fractures, Bone / virology
  • HIV Seropositivity / epidemiology*
  • Humans
  • Incidence
  • Infectious Disease Transmission, Vertical / statistics & numerical data*
  • Male
  • Prospective Studies
  • Risk Factors
  • United States / epidemiology

Substances

  • Anti-HIV Agents