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PLoS One. 2012;7(3):e34105. doi: 10.1371/journal.pone.0034105. Epub 2012 Mar 21.

Peptides of the constant region of antibodies display fungicidal activity.

Author information

1
Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Università degli Studi di Parma, Parma, Italy.

Abstract

Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.

PMID:
22470523
PMCID:
PMC3312352
DOI:
10.1371/journal.pone.0034105
[Indexed for MEDLINE]
Free PMC Article

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