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Antimicrob Agents Chemother. 2012 Jun;56(6):3435-7. doi: 10.1128/AAC.00060-12. Epub 2012 Apr 2.

Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise.

Author information

1
Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Abstract

While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0 °C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.

PMID:
22470114
PMCID:
PMC3370802
DOI:
10.1128/AAC.00060-12
[Indexed for MEDLINE]
Free PMC Article

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