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Emerg Infect Dis. 2012 Apr;18(4):660-3. doi: 10.3201/eid1804.110912.

Drug susceptibility of Mycobacterium tuberculosis Beijing genotype and association with MDR TB.

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1
Erasmus University Medical Center, Rotterdam, the Netherlands. j.desteenwinkel@erasmusmc.nl

Abstract

To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.

PMID:
22469099
PMCID:
PMC3309663
DOI:
10.3201/eid1804.110912
[Indexed for MEDLINE]
Free PMC Article
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