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Libyan J Med. 2012;7. doi: 10.3402/ljm.v7i0.16205. Epub 2012 Mar 27.

Antinociceptive activity of Mentha piperita leaf aqueous extract in mice.

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1
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Tripoli University, Tripoli, Libya.

Abstract

BACKGROUND:

Mentha piperita L. (Labiatae) is an herbaceous plant, used in folk medicine for the treatment of several medical disorders.

METHODS AND RESULTS:

In the present study, the aqueous extract of Mentha piperita leaf, at the i.p doses 200 and 400 mg/kg, showed significant analgesic effects against both acetic acid-induced writhing and hot plate-induced thermal stimulation in mice, with protection values of 51.79% and 20.21% respectively. On the contrary, the Mentha piperita leaf aqueous extract did not exhibit anti-inflammatory activity against carrageenan induced paw oedema.

CONCLUSION:

These findings indicate that Mentha piperita has a potential analgesic effect that may possibly have mediated centrally and peripherally, as well as providing a pharmacological evidence for its traditional use as a pain reliever.

KEYWORDS:

Mentha piperita; analgesic activity; mice; traditional medicine

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