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Z Gastroenterol. 2012 Apr;50(4):382-5. doi: 10.1055/s-0031-1273454. Epub 2012 Apr 1.

[With the scalpel against the immune system: HIV infection complicated by an unclear colitis].

[Article in German]

Author information

  • 1I. Med. Klinik und Poliklinik, Universitätsmedizin Mainz.


A 35-year-old Kenian lady with advanced immunodeficiency due to HIV infection started on an antiretroviral therapy. Five months later, a severe colitis was diagnosed, however, no causal pathogen could be found. In order to avoid imminent perforation, a hemicolectomy became necessary, and immediately the symptoms and inflammation markers normalized rapidly. M. tuberculosis could be proven in culture in a draining abdominal lymph node. We assume that the severe inflammation was caused by an immune restoration inflammatory syndrome (IRIS). Essentials in diagnosis, pathogenesis and therapy of IRIS are discussed.

[PubMed - indexed for MEDLINE]
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