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Nat Rev Microbiol. 2012 Apr 2;10(5):336-51. doi: 10.1038/nrmicro2762.

The type II secretion system: biogenesis, molecular architecture and mechanism.

Author information

1
Department of Biochemistry and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195, USA.

Abstract

Many gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our current knowledge of the biogenesis and architecture of the T2SS and its mechanism of action.

PMID:
22466878
PMCID:
PMC3705712
DOI:
10.1038/nrmicro2762
[Indexed for MEDLINE]
Free PMC Article

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