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Clin Cancer Res. 2012 May 15;18(10):2723-5. doi: 10.1158/1078-0432.CCR-12-0694. Epub 2012 Mar 31.

Metformin and pancreatic cancer: a clue requiring investigation.

Author information

1
Department of Oncology, Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada. michael.pollak@mcgill.ca

Abstract

Laboratory models show antineoplastic activity of metformin under certain conditions, and pharmacoepidemiologic studies have reported reduced cancer burden among diabetics taking metformin. Therefore, the hypothesis that metformin has antineoplastic activity is receiving increasing attention. However, gaps in knowledge must be addressed before metformin can be "repurposed" for oncologic indications.

PMID:
22465829
DOI:
10.1158/1078-0432.CCR-12-0694
[Indexed for MEDLINE]
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