Format

Send to

Choose Destination
Mol Cell Neurosci. 2012 May;50(1):10-20. doi: 10.1016/j.mcn.2012.03.005. Epub 2012 Mar 16.

The dendritic tree and brain disorders.

Author information

1
Department of Cell Biology and Neuroscience, 604 Allison Road, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Abstract

Dendrite morphogenesis is a complex but well-orchestrated process and includes the development of dendritic branches, forming characteristic dendrite arbors, and dendritic spines, allowing neurons to communicate with each other. Various studies report that many neuropsychiatric disorders are characterized by dendritic and synaptic pathology, including abnormal spine density and morphology, synapse loss, and aberrant synaptic signaling and plasticity. In this review, we discuss dendrite development and branching, and in specific, morphology, cytoskeletal architecture, and how the complexity of the dendrite tree and its functional capabilities are altered in various brain disorders. Identifying and understanding these changes in dendrite morphology are essential for understanding brain function in normal and disease states.

PMID:
22465229
DOI:
10.1016/j.mcn.2012.03.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center