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Drug Discov Today. 2012 Aug;17(15-16):850-60. doi: 10.1016/j.drudis.2012.03.002. Epub 2012 Mar 23.

Cell-penetrating peptides: classes, origin, and current landscape.

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Hoffmann-La Roche Inc., pRED Informatics, 340 Kingsland Street, Nutley, NJ, USA.


With more than ten new FDA approvals since 2001, peptides are emerging as an important therapeutic alternative to small molecules. However, unlike small molecules, peptides on the market today are limited to extracellular targets. By contrast, cell-penetrating peptides (CPPs) can target intracellular proteins and also carry other cargoes (e.g. other peptides, small molecules or proteins) into the cell, thus offering great potential as future therapeutics. In this review I present a classification scheme for CPPs based on their physical-chemical properties and origin, and I provide a general framework for understanding and discovering new CPPs.

[Indexed for MEDLINE]

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