Format

Send to

Choose Destination
Parkinsonism Relat Disord. 2012 Jun;18(5):645-8. doi: 10.1016/j.parkreldis.2012.03.006. Epub 2012 Mar 30.

Paroxysmal kinesigenic dyskinesia: cortical or non-cortical origin.

Author information

1
Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands.

Abstract

Paroxysmal kinesigenic dyskinesia (PKD) is characterized by involuntary dystonia and/or chorea triggered by a sudden movement. Cases are usually familial with an autosomal dominant inheritance. Hypotheses regarding the pathogenesis of PKD focus on the controversy whether PKD has a cortical or non-cortical origin. A combined familial trait of PKD and benign familial infantile seizures has been reported as the infantile convulsions and paroxysmal choreoathetosis (ICCA) syndrome. Here, we report a family diagnosed with ICCA syndrome with an Arg217STOP mutation. The index patient showed interictal EEG focal changes compatible with paroxysmal dystonic movements of his contralateral leg. This might support cortical involvement in PKD.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center