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Curr Opin Cell Biol. 2012 Jun;24(3):431-8. doi: 10.1016/j.ceb.2012.03.004. Epub 2012 Mar 29.

Structure, function and regulation of spliceosomal RNA helicases.

Author information

1
Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.

Abstract

Pre-mRNA splicing requires the activities of several ATPases from the DEAH-box, DEAD-box and Ski2-like helicase families to control conformational rearrangements within the spliceosome. Recent findings indicate that several spliceosomal helicases can act at multiple stages of the splicing reaction, and information on how those multiple actions are controlled are emerging. The recently solved crystal structure of the DEAH-box helicase Prp43 provides novel insights into the similarities and differences between the three helicase families. Here we discuss the potential family-specific mechanisms of spliceosomal RNA helicases and their regulation.

PMID:
22464735
DOI:
10.1016/j.ceb.2012.03.004
[Indexed for MEDLINE]

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