Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Endocrinol Metab. 2012 May;23(5):242-9. doi: 10.1016/j.tem.2012.02.008. Epub 2012 Mar 28.

Key questions and answers about pregnancy-associated plasma protein-A.

Author information

1
Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. Conover.Cheryl@Mayo.edu

Abstract

Twenty-five years after it was identified as a circulating protein of unknown function derived from the placenta, pregnancy-associated plasma protein-A (PAPP-A) was discovered to be a novel zinc metalloproteinase expressed by a variety of cell types. Great progress has been made in understanding the biology of PAPP-A and its regulation during recent years, especially in regard to physiological and pathophysiological inflammatory injury responses. However, much remains to be learned about this complex protein and its potential clinical implications outside pregnancy. In this article we address some of the outstanding questions about PAPP-A, in particular about its newly emerging role in the insulin-like growth factor (IGF) system.

PMID:
22463950
PMCID:
PMC3348390
DOI:
10.1016/j.tem.2012.02.008
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center