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Rev Sci Instrum. 2012 Mar;83(3):033108. doi: 10.1063/1.3694494.

A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue.

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1
Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA. mlf2129@columbia.edu

Abstract

We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid(®), ink, and dye.

PMID:
22462907
PMCID:
PMC3360692
DOI:
10.1063/1.3694494
[Indexed for MEDLINE]
Free PMC Article
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