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Clin Cases Miner Bone Metab. 2011 May;8(2):45-9.

Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses.

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1
Department of Radiology, University of Foggia, Foggia, Italy.

Abstract

BACKGROUND:

The phosphaturic mesenchymal tumor of the craniofacial sinuses (mixed connective tissue variant) is an extremely rare, distinctive paraneoplastic syndrome that is frequently associated with oncogenic osteomalacia.

METHODS:

In this report is presented a case of 22 years old man indicated four years of progressive generalized pain and weakness, eventually becoming wheel-chair bound. His current presentation was for chest pain resulting from atraumatic rib fractures.

RESULTS:

Imaging showed osteoporosis and multiple insufficiency fractures. CT and MRI showed an ethmoid mass. He had no symptoms referable to his nose or sinuses.

CONCLUSIONS:

The ethmoid lesion was completely excised, the patient's laboratory parameters returned to normal levels and the patient's symptoms disappeared.

KEYWORDS:

diagnostic imaging; insufficiency fracture; oncogenic osteomalacia; phosphaturic mesenchymal tumor

PMID:
22461817
PMCID:
PMC3279070
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