Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2012 Mar 30;335(6076):1617-21. doi: 10.1126/science.1212476.

Control of sleep by cyclin A and its regulator.

Author information

1
Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA.

Abstract

How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.

PMID:
22461610
PMCID:
PMC3380085
DOI:
10.1126/science.1212476
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center