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Curr Opin Neurobiol. 2012 Jun;22(3):389-96. doi: 10.1016/j.conb.2012.03.003. Epub 2012 Mar 27.

Signaling in dendritic spines and spine microdomains.

Author information

1
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States.

Abstract

The specialized morphology of dendritic spines creates an isolated compartment that allows for localized biochemical signaling. Recent studies have revealed complexity in the function of the spine head as a signaling domain and indicate that (1) the spine is functionally subdivided into multiple independent microdomains and (2) not all biochemical signals are equally compartmentalized within the spine. Here we review these findings as well as the developments in fluorescence microscopy that are making possible direct monitoring of signaling within spines and, in the future, within sub-spine microdomains.

PMID:
22459689
PMCID:
PMC3391315
DOI:
10.1016/j.conb.2012.03.003
[Indexed for MEDLINE]
Free PMC Article

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