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Exp Clin Endocrinol. 1990 Aug;95(3):339-43.

Decreased peripheral insulin sensitivity in acromegalic patients.

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1
Department of Medicine II, University of Vienna, Austria.

Abstract

In 13 nondiabetic acromegalic patients glucose homeostasis was studied by use of the hyperglycaemic clamp technique and compared to a group of sex and age matched and a group of sex, age and weight matched controls. When compared to a control group of normal weight glucose stimulated insulin release (I) was significantly increased and tissue sensitivity to insulin (M/I) significantly decreased. However, no significant differences were observed when the parameters were compared with a weight matched group. Glucose stimulated insulin release correlated positively with growth hormone (GH) and somatomedin-C levels, whereas no such a correlation could be obtained for M/I. Thus, chronic growth hormone excess seems to induce hyperinsulinaemia which in turn leads to obesity and metabolic changes comparable to those of obesity.

PMID:
2245822
DOI:
10.1055/s-0029-1210974
[Indexed for MEDLINE]

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