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J Nat Med. 2013 Jan;67(1):234-9. doi: 10.1007/s11418-012-0660-0. Epub 2012 Mar 29.

Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense.

Author information

1
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.

Abstract

We prepared a series of acerogenins A and B derivatives as inhibitors of nitric oxide (NO) production in vitro. Our results suggested that an ester group at a hydroxyl at C-2 improved inhibitory effects without cytotoxicity. A benzoyl ester derivative of acerogenin C showed the most potent inhibitory activity of NO production from lipopolysaccharide-activated macrophages.

PMID:
22456895
DOI:
10.1007/s11418-012-0660-0
[Indexed for MEDLINE]

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