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Curr Opin Chem Biol. 2012 Apr;16(1-2):109-16. doi: 10.1016/j.cbpa.2012.02.015. Epub 2012 Mar 26.

Biocatalysts and small molecule products from metagenomic studies.

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1
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States.

Abstract

The vast majority of bacteria present in environmental samples have never been cultured and therefore have not been exploited for the ability to produce useful biocatalysts or collections of biocatalysts generating interesting small molecules. Metagenomic libraries constructed using DNA extracted directly from natural bacterial communities offer access to the genetic information present in the genomes of these as yet uncultured bacteria. This review highlights recent efforts to recover both discrete enzymes and small molecules from metagenomic libraries.

PMID:
22455793
PMCID:
PMC3335775
DOI:
10.1016/j.cbpa.2012.02.015
[Indexed for MEDLINE]
Free PMC Article
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