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Clin Toxicol (Phila). 2012 Apr;50(4):262-5. doi: 10.3109/15563650.2012.670244.

Severe cobalt intoxication following hip replacement revision: clinical features and outcome.

Author information

1
Toxicological Information Centre, Department of Occupational Medicine, Charles University, Prague and General University Hospital, Czech Republic. daniela.pelclova@lf1.cuni.cz

Abstract

CONTEXT:

Cobalt intoxication has become more frequent due to the wide use of metal hip implants.

CASE DETAILS:

A 56-year-old male patient underwent total hip prosthesis, with a ceramics-on-ceramics implant. Almost 3 years later, it was replaced by metal implant containing cobalt, chromium, and titanium. He developed weight loss, heart, thyroid, and neurological toxicity, with severe hearing loss. He was treated with 2,3-dimercaptopropane-1-sulfonate (DMPS), and cobalt excretion increased. Clinical symptoms apart from deafness gradually resolved.

CONCLUSION:

We report significant cobalt poisoning from a damaged hip replacement with cobalt containing implant and a slow abrasion of the metal by residual ceramic particles. Chelation therapy resulted in apparent benefit.

PMID:
22455358
DOI:
10.3109/15563650.2012.670244
[Indexed for MEDLINE]
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