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J Neuroimmune Pharmacol. 2012 Dec;7(4):740-9. doi: 10.1007/s11481-012-9359-y. Epub 2012 Mar 28.

Wnt/beta-catenin signaling in glioma.

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1
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China.

Abstract

Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors in Wnt/beta-catenin signaling, and crosstalk with other signaling pathways. Finally, we discuss the involvement of microRNAs in Wnt/beta-catenin signaling in glioma. This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway.

PMID:
22454041
DOI:
10.1007/s11481-012-9359-y
[Indexed for MEDLINE]
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